Ram Dixit , Proteins by Tau Differential Regulation of Dynein and Kinesin Motor
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چکیده
http://www.sciencemag.org/cgi/content/full/319/5866/1086 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1152993/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/319/5866/1086#related-content http://www.sciencemag.org/cgi/content/full/319/5866/1086#otherarticles , 7 of which can be accessed for free: cites 20 articles This article 7 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/319/5866/1086#otherarticles 2 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology : subject collections This article appears in the following
منابع مشابه
Differential regulation of dynein and kinesin motor proteins by tau.
Dynein and kinesin motor proteins transport cellular cargoes toward opposite ends of microtubule tracks. In neurons, microtubules are abundantly decorated with microtubule-associated proteins (MAPs) such as tau. Motor proteins thus encounter MAPs frequently along their path. To determine the effects of tau on dynein and kinesin motility, we conducted single-molecule studies of motor proteins mo...
متن کاملProteins by Tau Differential Regulation of Dynein and Kinesin Motor
www.sciencemag.org (this information is current as of March 19, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/319/5866/1086 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1152993/DC1 can be found at: ...
متن کاملTuning microtubule-based transport through filamentous MAPs: the problem of dynein.
We recently proposed that regulating the single-to-multiple motor transition was a likely strategy for regulating kinesin-based transport in vivo. In this study, we use an in vitro bead assay coupled with an optical trap to investigate how this proposed regulatory mechanism affects dynein-based transport. We show that tau's regulation of kinesin function can proceed without interfering with dyn...
متن کاملTau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams.
Organelles, proteins, and mRNA are transported bidirectionally along microtubules by plus-end directed kinesin and minus-end directed dynein motors. Microtubules are decorated by microtubule-associated proteins (MAPs) that organize the cytoskeleton, regulate microtubule dynamics and modulate the interaction between motor proteins and microtubules to direct intracellular transport. Tau is a neur...
متن کاملEffect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A.
Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins...
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تاریخ انتشار 2011